FSpaceRPG article

Status: Official

One of more flexible strategies for gene therapy compared to viral vectors is the use of plasmids, or circular DNA which is used by bacteria. They have the advantage of being larger and can handle large genes.

Plasmids are the way through which bacteria exchange DNA and in the early days of research was the most common method to use so as not to immune response from the patient.

The one problem with the technique is that plasmids are not readily integrated into the patients genome and is considerably slower to make any changes. However when combined with other techniques is has been found to be an effective solution where timing is not important.

Bacteria are also used to store genes of interest for long periods of time as well.

Categories: Medical

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